Molecular Epidemiology of Neisseria meningitidis Serogroup B in Brazil
Identifieur interne : 000479 ( Main/Exploration ); précédent : 000478; suivant : 000480Molecular Epidemiology of Neisseria meningitidis Serogroup B in Brazil
Auteurs : Ivano De Filippis [Brésil, États-Unis] ; Ana Paula S. De Lemos [Brésil] ; Jessica B. Hostetler [États-Unis] ; Kurt Wollenberg [États-Unis] ; Claudio T. Sacchi [Brésil] ; Lee H. Harrison [États-Unis] ; Margaret C. Bash [États-Unis] ; D. Rebecca Prevots [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
We performed multi-locus sequence typing (MLST) and sequence analysis of five outer membrane protein (OMP) genes, including novel vaccine targets
In 2004, strain B:4:P1.15,19 clonal complex ST-32/ET-5 (cc32) predominated throughout Brazil; regional variation in MLST sequence type (ST),
A predominant serogroup B lineage has circulated in Brazil for over a decade with significant regional and temporal diversity in ST,
Url:
DOI: 10.1371/journal.pone.0033016
PubMed: 22431994
PubMed Central: 3303791
Affiliations:
- Brésil, États-Unis
- Maryland, Pennsylvanie, État de Rio de Janeiro
- Pittsburgh, Rio de Janeiro
- Université de Pittsburgh
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De Lemos</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Bacteriology, Instituto Adolfo Lutz (IAL), São Paolo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Bacteriology, Instituto Adolfo Lutz (IAL), São Paolo</wicri:regionArea><wicri:noRegion>São Paolo</wicri:noRegion></affiliation></author><author><name sortKey="Hostetler, Jessica B" sort="Hostetler, Jessica B" uniqKey="Hostetler J" first="Jessica B." last="Hostetler">Jessica B. Hostetler</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>J. Craig Venter Institute (JCVI), Rockville, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>J. Craig Venter Institute (JCVI), Rockville, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Wollenberg, Kurt" sort="Wollenberg, Kurt" uniqKey="Wollenberg K" first="Kurt" last="Wollenberg">Kurt Wollenberg</name><affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Office of Cyberinfrastructure and Computational Biology (OCICB), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Office of Cyberinfrastructure and Computational Biology (OCICB), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Sacchi, Claudio T" sort="Sacchi, Claudio T" uniqKey="Sacchi C" first="Claudio T." last="Sacchi">Claudio T. Sacchi</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Department of Immunology, Instituto Adolfo Lutz, São Paolo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Immunology, Instituto Adolfo Lutz, São Paolo</wicri:regionArea><wicri:noRegion>São Paolo</wicri:noRegion></affiliation></author><author><name sortKey="Harrison, Lee H" sort="Harrison, Lee H" uniqKey="Harrison L" first="Lee H." last="Harrison">Lee H. Harrison</name><affiliation wicri:level="4"><nlm:aff id="aff8"><addr-line>Infectious Diseases Epidemiology Research Unit, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Infectious Diseases Epidemiology Research Unit, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Bash, Margaret C" sort="Bash, Margaret C" uniqKey="Bash M" first="Margaret C." last="Bash">Margaret C. Bash</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Prevots, D Rebecca" sort="Prevots, D Rebecca" uniqKey="Prevots D" first="D. Rebecca" last="Prevots">D. Rebecca Prevots</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Epidemiology Unit, Laboratory of Clinical Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Unit, Laboratory of Clinical Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22431994</idno><idno type="pmc">3303791</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303791</idno><idno type="RBID">PMC:3303791</idno><idno type="doi">10.1371/journal.pone.0033016</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000645</idno><idno type="wicri:Area/Pmc/Curation">000645</idno><idno type="wicri:Area/Pmc/Checkpoint">000390</idno><idno type="wicri:Area/Ncbi/Merge">000294</idno><idno type="wicri:Area/Ncbi/Curation">000294</idno><idno type="wicri:Area/Ncbi/Checkpoint">000294</idno><idno type="wicri:Area/Main/Merge">000480</idno><idno type="wicri:Area/Main/Curation">000479</idno><idno type="wicri:Area/Main/Exploration">000479</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Molecular Epidemiology of <italic>Neisseria meningitidis</italic> Serogroup B in Brazil</title><author><name sortKey="De Filippis, Ivano" sort="De Filippis, Ivano" uniqKey="De Filippis I" first="Ivano" last="De Filippis">Ivano De Filippis</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>National Quality Control Institute (INCQS), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>National Quality Control Institute (INCQS), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro</wicri:regionArea><placeName><settlement type="city">Rio de Janeiro</settlement><region type="state">État de Rio de Janeiro</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Epidemiology Unit, Laboratory of Clinical Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Unit, Laboratory of Clinical Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="De Lemos, Ana Paula S" sort="De Lemos, Ana Paula S" uniqKey="De Lemos A" first="Ana Paula S." last="De Lemos">Ana Paula S. De Lemos</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Bacteriology, Instituto Adolfo Lutz (IAL), São Paolo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Bacteriology, Instituto Adolfo Lutz (IAL), São Paolo</wicri:regionArea><wicri:noRegion>São Paolo</wicri:noRegion></affiliation></author><author><name sortKey="Hostetler, Jessica B" sort="Hostetler, Jessica B" uniqKey="Hostetler J" first="Jessica B." last="Hostetler">Jessica B. Hostetler</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>J. Craig Venter Institute (JCVI), Rockville, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>J. Craig Venter Institute (JCVI), Rockville, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Wollenberg, Kurt" sort="Wollenberg, Kurt" uniqKey="Wollenberg K" first="Kurt" last="Wollenberg">Kurt Wollenberg</name><affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Office of Cyberinfrastructure and Computational Biology (OCICB), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Office of Cyberinfrastructure and Computational Biology (OCICB), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Sacchi, Claudio T" sort="Sacchi, Claudio T" uniqKey="Sacchi C" first="Claudio T." last="Sacchi">Claudio T. Sacchi</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Department of Immunology, Instituto Adolfo Lutz, São Paolo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Immunology, Instituto Adolfo Lutz, São Paolo</wicri:regionArea><wicri:noRegion>São Paolo</wicri:noRegion></affiliation></author><author><name sortKey="Harrison, Lee H" sort="Harrison, Lee H" uniqKey="Harrison L" first="Lee H." last="Harrison">Lee H. Harrison</name><affiliation wicri:level="4"><nlm:aff id="aff8"><addr-line>Infectious Diseases Epidemiology Research Unit, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Infectious Diseases Epidemiology Research Unit, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Bash, Margaret C" sort="Bash, Margaret C" uniqKey="Bash M" first="Margaret C." last="Bash">Margaret C. Bash</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Prevots, D Rebecca" sort="Prevots, D Rebecca" uniqKey="Prevots D" first="D. Rebecca" last="Prevots">D. Rebecca Prevots</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Epidemiology Unit, Laboratory of Clinical Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Unit, Laboratory of Clinical Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p><italic>Neisseria meningitidis</italic> serogroup B has been predominant in Brazil, but no broadly effective vaccine is available to prevent endemic meningococcal disease. To understand genetic diversity among serogroup B strains in Brazil, we selected a nationally representative sample of clinical disease isolates from 2004, and a temporally representative sample for the state of São Paulo (1988–2006) for study (n = 372).</p></sec><sec><title>Methods</title><p>We performed multi-locus sequence typing (MLST) and sequence analysis of five outer membrane protein (OMP) genes, including novel vaccine targets <italic>fHbp</italic> and <italic>nadA</italic>.</p></sec><sec><title>Results</title><p>In 2004, strain B:4:P1.15,19 clonal complex ST-32/ET-5 (cc32) predominated throughout Brazil; regional variation in MLST sequence type (ST), <italic>fetA</italic>, and <italic>porB</italic> was significant but diversity was limited for <italic>nadA</italic> and <italic>fHbp</italic>. Between 1988 and 1996, the São Paulo isolates shifted from clonal complex ST-41/44/Lineage 3 (cc41/44) to cc32. OMP variation was associated with but not predicted by cc or ST. Overall, <italic>fHbp</italic> variant 1/subfamily B was present in 80% of isolates and showed little diversity. The majority of <italic>nadA</italic> were similar to reference allele 1.</p></sec><sec><title>Conclusions</title><p>A predominant serogroup B lineage has circulated in Brazil for over a decade with significant regional and temporal diversity in ST, <italic>fetA</italic>, and <italic>porB</italic>, but not in <italic>nadA</italic> and <italic>fHbp</italic>.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Sacchi, Ct" uniqKey="Sacchi C">CT Sacchi</name></author><author><name sortKey="Pessoa, Ll" uniqKey="Pessoa L">LL Pessoa</name></author><author><name sortKey="Ramos, Sr" uniqKey="Ramos S">SR Ramos</name></author><author><name sortKey="Milagres, Lc" uniqKey="Milagres L">LC Milagres</name></author><author><name sortKey="Camargo, Mcc" uniqKey="Camargo M">MCC Camargo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Lemos, Ap" uniqKey="De Lemos A">AP de Lemos</name></author><author><name sortKey="Yara, Ty" uniqKey="Yara T">TY Yara</name></author><author><name sortKey="Gorla, Mc" uniqKey="Gorla M">MC Gorla</name></author><author><name sortKey="Paiva, Mv" uniqKey="Paiva M">MV Paiva</name></author><author><name sortKey="De Souza, Al" uniqKey="De Souza A">AL de Souza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holst, J" uniqKey="Holst J">J Holst</name></author><author><name sortKey="Martin, D" uniqKey="Martin D">D Martin</name></author><author><name sortKey="Arnold, R" uniqKey="Arnold R">R Arnold</name></author><author><name sortKey="Huergo, Cc" uniqKey="Huergo C">CC Huergo</name></author><author><name sortKey="Oster, P" uniqKey="Oster P">P Oster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pizza, M" uniqKey="Pizza M">M Pizza</name></author><author><name sortKey="Scarlato, V" uniqKey="Scarlato V">V Scarlato</name></author><author><name sortKey="Masignani, V" uniqKey="Masignani V">V Masignani</name></author><author><name sortKey="Giuliani, Mm" uniqKey="Giuliani M">MM Giuliani</name></author><author><name sortKey="Arica, B" uniqKey="Arica B">B Arica</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fletcher, Ld" uniqKey="Fletcher L">LD Fletcher</name></author><author><name sortKey="Bernfield, L" uniqKey="Bernfield L">L Bernfield</name></author><author><name sortKey="Barniak, V" uniqKey="Barniak V">V Barniak</name></author><author><name sortKey="Farley, Je" uniqKey="Farley J">JE Farley</name></author><author><name sortKey="Howell, A" uniqKey="Howell A">A Howell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giuliani, Mm" uniqKey="Giuliani M">MM Giuliani</name></author><author><name sortKey="Adu Bobie, J" uniqKey="Adu Bobie J">J Adu-Bobie</name></author><author><name sortKey="Comanducci, M" uniqKey="Comanducci M">M Comanducci</name></author><author><name sortKey="Arico, B" uniqKey="Arico B">B Arico</name></author><author><name sortKey="Savino, B" uniqKey="Savino B">B Savino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cordeiro, Sm" uniqKey="Cordeiro S">SM Cordeiro</name></author><author><name sortKey="Neves, Ab" uniqKey="Neves A">AB Neves</name></author><author><name sortKey="Ribeiro, Ct" uniqKey="Ribeiro C">CT Ribeiro</name></author><author><name sortKey="Petersen, Ml" uniqKey="Petersen M">ML Petersen</name></author><author><name sortKey="Gouveia, El" uniqKey="Gouveia E">EL Gouveia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baethgen, Lf" uniqKey="Baethgen L">LF Baethgen</name></author><author><name sortKey="Weidlich, L" uniqKey="Weidlich L">L Weidlich</name></author><author><name sortKey="Moraes, C" uniqKey="Moraes C">C Moraes</name></author><author><name sortKey="Klein, C" uniqKey="Klein C">C Klein</name></author><author><name sortKey="Nunes, Ls" uniqKey="Nunes L">LS Nunes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Filippis, I" uniqKey="De Filippis I">I de Filippis</name></author><author><name sortKey="Vicente, Ac" uniqKey="Vicente A">AC Vicente</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sacchi, Ct" uniqKey="Sacchi C">CT Sacchi</name></author><author><name sortKey="Lemos, Ap" uniqKey="Lemos A">AP Lemos</name></author><author><name sortKey="Popovic, T" uniqKey="Popovic T">T Popovic</name></author><author><name sortKey="De Moraes, Jc" uniqKey="De Moraes J">JC de Moraes</name></author><author><name sortKey="Whitney, Am" uniqKey="Whitney A">AM Whitney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Comanducci, M" uniqKey="Comanducci M">M Comanducci</name></author><author><name sortKey="Bambini, S" uniqKey="Bambini S">S Bambini</name></author><author><name sortKey="Brunelli, B" uniqKey="Brunelli B">B Brunelli</name></author><author><name sortKey="Adu Babie, J" uniqKey="Adu Babie J">J Adu-Babie</name></author><author><name sortKey="Arico, B" uniqKey="Arico B">B Arico</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Masignani, V" uniqKey="Masignani V">V Masignani</name></author><author><name sortKey="Comanducci, M" uniqKey="Comanducci M">M Comanducci</name></author><author><name sortKey="Giuliani, Mm" uniqKey="Giuliani M">MM Giuliani</name></author><author><name sortKey="Bambini, S" uniqKey="Bambini S">S Bambini</name></author><author><name sortKey="Adu Babie, J" uniqKey="Adu Babie J">J Adu-Babie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Madico, G" uniqKey="Madico G">G Madico</name></author><author><name sortKey="Welsch, Ja" uniqKey="Welsch J">JA Welsch</name></author><author><name sortKey="Lewis, La" uniqKey="Lewis L">LA Lewis</name></author><author><name sortKey="Mcnaughton, A" uniqKey="Mcnaughton A">A McNaughton</name></author><author><name sortKey="Perlman, Dh" uniqKey="Perlman D">DH Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maiden, Mc" uniqKey="Maiden M">MC Maiden</name></author><author><name sortKey="Bygraves, Ja" uniqKey="Bygraves J">JA Bygraves</name></author><author><name sortKey="Feil, E" uniqKey="Feil E">E Feil</name></author><author><name sortKey="Morelli, G" uniqKey="Morelli G">G Morelli</name></author><author><name sortKey="Russell, Je" uniqKey="Russell J">JE Russell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suker, J" uniqKey="Suker J">J Suker</name></author><author><name sortKey="Feavers, Im" uniqKey="Feavers I">IM Feavers</name></author><author><name sortKey="Achtman, M" uniqKey="Achtman M">M Achtman</name></author><author><name sortKey="Morelli, G" uniqKey="Morelli G">G Morelli</name></author><author><name sortKey="Wang, Jf" uniqKey="Wang J">JF Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Urwin, R" uniqKey="Urwin R">R Urwin</name></author><author><name sortKey="Kaczmarski, Eb" uniqKey="Kaczmarski E">EB Kaczmarski</name></author><author><name sortKey="Guiver, M" uniqKey="Guiver M">M Guiver</name></author><author><name sortKey="Fox, Aj" uniqKey="Fox A">AJ Fox</name></author><author><name sortKey="Maiden, Mm" uniqKey="Maiden M">MM Maiden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thompson, Ea" uniqKey="Thompson E">EA Thompson</name></author><author><name sortKey="Feavers, Im" uniqKey="Feavers I">IM Feavers</name></author><author><name sortKey="Maiden, Mc" uniqKey="Maiden M">MC Maiden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sutton, Gg" uniqKey="Sutton G">GG Sutton</name></author><author><name sortKey="Adams, Md" uniqKey="Adams M">MD Adams</name></author><author><name sortKey="Kervlage, Ar" uniqKey="Kervlage A">AR Kervlage</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thompson, Jd" uniqKey="Thompson J">JD Thompson</name></author><author><name sortKey="Gibson, Tj" uniqKey="Gibson T">TJ Gibson</name></author><author><name sortKey="Higgins, Dg" uniqKey="Higgins D">DG Higgins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hall, T" uniqKey="Hall T">T Hall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jolley, Ka" uniqKey="Jolley K">KA Jolley</name></author><author><name sortKey="Maiden, Mc" uniqKey="Maiden M">MC Maiden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Edgar, Rc" uniqKey="Edgar R">RC Edgar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Didelot, X" uniqKey="Didelot X">X Didelot</name></author><author><name sortKey="Falush, D" uniqKey="Falush D">D Falush</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Swofford, D" uniqKey="Swofford D">D Swofford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Comanducci, M" uniqKey="Comanducci M">M Comanducci</name></author><author><name sortKey="Bambini, S" uniqKey="Bambini S">S Bambini</name></author><author><name sortKey="Caugant, Da" uniqKey="Caugant D">DA Caugant</name></author><author><name sortKey="Mora, M" uniqKey="Mora M">M Mora</name></author><author><name sortKey="Brunelli, B" uniqKey="Brunelli B">B Brunelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jolley, Ka" uniqKey="Jolley K">KA Jolley</name></author><author><name sortKey="Brehoney, C" uniqKey="Brehoney C">C Brehoney</name></author><author><name sortKey="Maiden, Mc" uniqKey="Maiden M">MC Maiden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barroso, De" uniqKey="Barroso D">DE Barroso</name></author><author><name sortKey="Carvalho, Dm" uniqKey="Carvalho D">DM Carvalho</name></author><author><name sortKey="Casagrande, St" uniqKey="Casagrande S">ST Casagrande</name></author><author><name sortKey="Rebelo, Mc" uniqKey="Rebelo M">MC Rebelo</name></author><author><name sortKey="Soares, V" uniqKey="Soares V">V Soares</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sacchi, Ct" uniqKey="Sacchi C">CT Sacchi</name></author><author><name sortKey="Lemos, Ap" uniqKey="Lemos A">AP Lemos</name></author><author><name sortKey="Brandt, Me" uniqKey="Brandt M">ME Brandt</name></author><author><name sortKey="Whitney, Am" uniqKey="Whitney A">AM Whitney</name></author><author><name sortKey="Melles, Cea" uniqKey="Melles C">CEA Melles</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Russell, Je" uniqKey="Russell J">JE Russell</name></author><author><name sortKey="Urwin, R" uniqKey="Urwin R">R Urwin</name></author><author><name sortKey="Gray, Sj" uniqKey="Gray S">SJ Gray</name></author><author><name sortKey="Fox, Aj" uniqKey="Fox A">AJ Fox</name></author><author><name sortKey="Feavers, Im" uniqKey="Feavers I">IM Feavers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Urwin, R" uniqKey="Urwin R">R Urwin</name></author><author><name sortKey="Russell, Je" uniqKey="Russell J">JE Russell</name></author><author><name sortKey="Thompson, Ea" uniqKey="Thompson E">EA Thompson</name></author><author><name sortKey="Holmes, Ec" uniqKey="Holmes E">EC Holmes</name></author><author><name sortKey="Feavers, Im" uniqKey="Feavers I">IM Feavers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Findlow, J" uniqKey="Findlow J">J Findlow</name></author><author><name sortKey="Borrow, R" uniqKey="Borrow R">R Borrow</name></author><author><name sortKey="Snape, Md" uniqKey="Snape M">MD Snape</name></author><author><name sortKey="Dawson, T" uniqKey="Dawson T">T Dawson</name></author><author><name sortKey="Holland, A" uniqKey="Holland A">A Holland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, Hq" uniqKey="Jiang H">HQ Jiang</name></author><author><name sortKey="Hoiseth, Sk" uniqKey="Hoiseth S">SK Hoiseth</name></author><author><name sortKey="Harris, Sl" uniqKey="Harris S">SL Harris</name></author><author><name sortKey="Mcneil, Lk" uniqKey="Mcneil L">LK McNeil</name></author><author><name sortKey="Zhu, D" uniqKey="Zhu D">D Zhu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, Pb" uniqKey="Keiser P">PB Keiser</name></author><author><name sortKey="Biggs Cicatelli, S" uniqKey="Biggs Cicatelli S">S Biggs-Cicatelli</name></author><author><name sortKey="Moran, Ee" uniqKey="Moran E">EE Moran</name></author><author><name sortKey="Schmeil, Dh" uniqKey="Schmeil D">DH Schmeil</name></author><author><name sortKey="Pinto, Vb" uniqKey="Pinto V">VB Pinto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lucidarme, J" uniqKey="Lucidarme J">J Lucidarme</name></author><author><name sortKey="Comanducci, M" uniqKey="Comanducci M">M Comanducci</name></author><author><name sortKey="Findlow, J" uniqKey="Findlow J">J Findlow</name></author><author><name sortKey="Gray, Sj" uniqKey="Gray S">SJ Gray</name></author><author><name sortKey="Kaczmarski, Eb" uniqKey="Kaczmarski E">EB Kaczmarski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bambini, S" uniqKey="Bambini S">S Bambini</name></author><author><name sortKey="Muzzi, A" uniqKey="Muzzi A">A Muzzi</name></author><author><name sortKey="Olcen, P" uniqKey="Olcen P">P Olcen</name></author><author><name sortKey="Rappuoli, R" uniqKey="Rappuoli R">R Rappuoli</name></author><author><name sortKey="Pizza, M" uniqKey="Pizza M">M Pizza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murphy, E" uniqKey="Murphy E">E Murphy</name></author><author><name sortKey="Andrew, L" uniqKey="Andrew L">L Andrew</name></author><author><name sortKey="Lee, Kl" uniqKey="Lee K">KL Lee</name></author><author><name sortKey="Ditts, Da" uniqKey="Ditts D">DA Ditts</name></author><author><name sortKey="Nunuez, L" uniqKey="Nunuez L">L Nunuez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author><author><name sortKey="Cohn, A" uniqKey="Cohn A">A Cohn</name></author><author><name sortKey="Comanducci, M" uniqKey="Comanducci M">M Comanducci</name></author><author><name sortKey="Andrew, L" uniqKey="Andrew L">L Andrew</name></author><author><name sortKey="Zhao, X" uniqKey="Zhao X">X Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pajon, R" uniqKey="Pajon R">R Pajon</name></author><author><name sortKey="Beernink, Pt" uniqKey="Beernink P">PT Beernink</name></author><author><name sortKey="Harrison, Lh" uniqKey="Harrison L">LH Harrison</name></author><author><name sortKey="Granoff, Dm" uniqKey="Granoff D">DM Granoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brehony, C" uniqKey="Brehony C">C Brehony</name></author><author><name sortKey="Jolley, Ka" uniqKey="Jolley K">KA Jolley</name></author><author><name sortKey="Maiden, Mc" uniqKey="Maiden M">MC Maiden</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Brésil</li><li>États-Unis</li></country><region><li>Maryland</li><li>Pennsylvanie</li><li>État de Rio de Janeiro</li></region><settlement><li>Pittsburgh</li><li>Rio de Janeiro</li></settlement><orgName><li>Université de Pittsburgh</li></orgName></list><tree><country name="Brésil"><region name="État de Rio de Janeiro"><name sortKey="De Filippis, Ivano" sort="De Filippis, Ivano" uniqKey="De Filippis I" first="Ivano" last="De Filippis">Ivano De Filippis</name></region><name sortKey="De Lemos, Ana Paula S" sort="De Lemos, Ana Paula S" uniqKey="De Lemos A" first="Ana Paula S." last="De Lemos">Ana Paula S. De Lemos</name><name sortKey="Sacchi, Claudio T" sort="Sacchi, Claudio T" uniqKey="Sacchi C" first="Claudio T." last="Sacchi">Claudio T. Sacchi</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="De Filippis, Ivano" sort="De Filippis, Ivano" uniqKey="De Filippis I" first="Ivano" last="De Filippis">Ivano De Filippis</name></region><name sortKey="Bash, Margaret C" sort="Bash, Margaret C" uniqKey="Bash M" first="Margaret C." last="Bash">Margaret C. Bash</name><name sortKey="De Filippis, Ivano" sort="De Filippis, Ivano" uniqKey="De Filippis I" first="Ivano" last="De Filippis">Ivano De Filippis</name><name sortKey="Harrison, Lee H" sort="Harrison, Lee H" uniqKey="Harrison L" first="Lee H." last="Harrison">Lee H. Harrison</name><name sortKey="Hostetler, Jessica B" sort="Hostetler, Jessica B" uniqKey="Hostetler J" first="Jessica B." last="Hostetler">Jessica B. Hostetler</name><name sortKey="Prevots, D Rebecca" sort="Prevots, D Rebecca" uniqKey="Prevots D" first="D. Rebecca" last="Prevots">D. Rebecca Prevots</name><name sortKey="Wollenberg, Kurt" sort="Wollenberg, Kurt" uniqKey="Wollenberg K" first="Kurt" last="Wollenberg">Kurt Wollenberg</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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